A study on the reaction of 16-dehydropregnenolone acetate with 2-aminobenzimidazole

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• 作者：Agnieszka Wojtkielewicz ; ^{jeremy@uwb.edu.pl} ; Paulina Uścinowicz ; Leszek Siergiejczyk ; Urszula Kiełczewska ; Artur Ratkiewicz ; Jacek W. Morzycki
• 关键词：2-Aminobenzimidazole ; Condensation ; α-Ketol rearrangement ; Autoxidation ; Steroids
• 刊名：Steroids
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：117
• 期：Complete
• 页码：71-76
• 全文大小：990 K
• 卷排序：117

文摘

The reaction between 16-dehydropregnenolone acetate and 2-aminobenzimidazole was investigated as an easy way to obtain pyrimidinobenzimidazole derivative. The reaction mechanism based on experimental evidences as well as DFT calculations was proposed. D-homo ketone byproduct was formed in α-ketol type rearrangement. The strong solvent effect on the condensation process was revealed.