Simulation of the M13 life cycle II: Investigation of the control mechanisms of M13 infection and establishment of the carrier state

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• 作者：Steven W. Smeal^a ; Margaret A. Schmitt^a ; Ronnie Rodrigues Pereira^a ; Ashok Prasad^a ; John D. Fisk^a ; ^b ; ^c ; ^{nickfisk@colostate.edu}
• 关键词：M13 bacteriophage ; Computational biology ; Virus life cycle ; Systems biology ; Genetically-structured simulation
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：275-284
• 全文大小：1988 K
• 卷排序：500

文摘

Kinetic simulation of M13 explores the mechanism of host-phage resource allocation. Supports role of phage protein-based translational attenuation as key control element. Finds new role for translational attenuation in prioritization of resource usage. Curing of infection is due to phage-controlled dilution without replacement of RF-DNA.