Multiple beneficial effects of melanocortin MC₄ receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives

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• 作者：Daniela Giuliani^a ; Alessandra Ottani^a ; Laura Neri^a ; Davide Zaffe^b ; Paolo Grieco^c ; Jerzy Jochem^d ; Gian Maria Cavallini^e ; Anna Catania^f ; Salvatore Guarini^a ; ^{salvatore.guarini@unimore.it}
• 关键词：Aβ ; β-amyloid ; ACTH ; adrenocorticotropic hormone ; AD ; Alzheimer&rsquo ; s disease ; BDNF ; brain-derived neurotrophic factor ; BrdU ; 5-bromo-2&prime ; -deoxyuridine ; CNS ; central nervous system ; DG ; dentate gyrus ; ERK ; extracellular signal-regulated kinases ; HMGB-1 ; high Mobility Group Box-1 ; JNK ; c-jun N-terminal kinases ; MSH ; melanocyte-stimulating hormone ; NDP-α-MSH ; [Nle4 ; D-Phe7]α-melanocyte-stimulating hormone ; SAH ; subarachnoid hemorrhage ; SCI ; spinal cord injury ; SGZ ; subgranular zone ; Shh ; soni
• 刊名：Progress in Neurobiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：148
• 期：Complete
• 页码：40-56
• 全文大小：1918 K
• 卷排序：148

文摘

Melanocortins induce neuroprotection and neurogenesis in neurodegenerative disorders. Melanocortins improve synaptic activity and neurological performance. These effects are mediated by melanocortin MC4 receptors.