Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome

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• 作者：Xian Liu¹ ; Tristan R. Grogan³ ; Haley Hieronymus⁴ ; Takao Hashimoto¹ ; Jack Mottahedeh¹ ; Donghui Cheng⁵ ; Lijun Zhang² ; Kevin Huang² ; Tanya Stoyanova⁶ ; ¹⁵ ; Jung Wook Park⁶ ; Ruzanna O. Shkhyan¹ ; Behdokht Nowroozizadeh⁷ ; Matthew B. Rettig⁸ ; ⁹ ; ¹⁰ ; ¹¹ ; Charles L. Sawyers⁴ ; David Elashoff³ ; ¹¹ ; Steve Horvath¹² ; ¹³ ; Jiaoti Huang⁵ ; ⁷ ; ¹¹ ; ¹⁶ ; Owen N. Witte² ; ⁵ ; ⁶ ; ¹¹ ; ¹⁴ ; Andrew S. Goldstein¹ ; ⁵ ; ¹⁰ ; ¹¹ ; ¹⁷ ; ^{agoldstein@mednet.ucla.edu}
• 关键词：prostate cancer ; stem cells ; progenitor ; inflammation ; luminal ; CD38 ; transformation ; cell of origin
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2596-2606
• 全文大小：5276 K
• 卷排序：17

文摘

Low expression of CD38 enriches for luminal progenitor cells in human prostate CD38lo luminal cells are localized in proximity to prostatic inflammation CD38lo luminal cells are target cells for aggressive human prostate cancer Low CD38 in prostate cancer is prognostic for biochemical recurrence and metastasis