Single stranded siRNA complexation through non-electrostatic interactions
详细信息 查看全文
- 作者：Lucie Girauda ; Warren Viricela ; Jeanne Leblonda ; Suzanne Giassona ; b ; suzanne.giasson@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Single stranded RNA ; Surfaces Forces Apparatus ; Hydrophobic interactions ; Hydrogen bonding
- 刊名：Biomaterials
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：113
- 期：Complete
- 页码：230-242
- 全文大小：3272 K
文摘
- •
Single stranded siRNA (ss-siRNA) can adsorb on hydrophilic and hydrophobic surfaces.
- •
ss-siRNA can self-assemble on surfaces through non-electrostatic interactions.
- •
The ss-siRNA conformation depends on the nature of the interactions with the surface.
- •
ss-siRNA can be loaded into uncharged and negatively charged nanocarriers.
- •
Quantification of ss-siRNA loading can be biased with unconventional nanocarriers.