Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control
详细信息 查看全文
- 作者：Massimo Trusel1 ; 6 ; Anna Cavaccini1 ; 6 ; Marta Gritti1 ; 2 ; Barbara Greco1 ; Pierre-Philippe Saintot1 ; Cristiano Nazzaro1 ; Milica Cerovic3 ; 4 ; Ilaria Morella4 ; 5 ; Riccardo Brambilla3 ; 4 ; Raffaella Tonini1 ; raffaella.tonini@iit.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：13
- 期：7
- 页码：1353-1365
- 全文大小：4008 K
文摘
- •
eCBs govern LTD in striatopallidal neurons and adenosine does so in striatonigral cells
- •
Parkinson’s disease (PD)-like dopamine (DA) depletion impairs eCB-, but not adenosine-LTD
- •
DA deficits are circumvented by resuming cell-type-specific eCB and ERK signaling
- •
Segregated modulation of eCB and ERK signaling alleviates PD motor abnormalities
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |