Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study

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• 作者：Emilia Salvadori^a ; Anna Poggesi^a ; Raffaella Valenti^a ; Giovanni Pracucci^a ; Francesca Pescini^b ; Marco Pasi^a ; Serena Nannucci^a ; Sandro Marini^a ; Alessandra Del Bene^a ; Laura Ciolli^a ; Andrea Ginestroni^c ; Stefano Diciotti^d ; Giovanni Orlandi^e ; Ilaria Di Donato^f ; Nicola De Stefano^f ; ¹ ; Mirco Cosottini^g ; Alberto Chiti^e ; Antonio Federico^f ; Maria Teresa Dotti^f ; Ubaldo Bonuccelli^e ; Domenico Inzitari^a ; ² ; Leonardo Pantoni^a ; ^b ; ³ ; ^{leonardo.pantoni@unifi.it" class="auth_mail" title="E-mail the corresponding author} ; on behalf of the VMCI-Tuscany Study GroupDomenico Inzitari ; Rosanna Abbate ; Maria Boddi ; Francesca Cesari ; Laura Ciolli ; Mirella Coppo ; Alessandra Del Bene ; Stefano Diciotti ; Andrea Ginestroni ; Betti Giusti ; Anna Maria Gori ; Sandro Marini ; Mario Mascalchi ; Serena Nannucci ; Leonardo Pantoni ; Marco Pasi ; Francesca Pescini ; Anna Poggesi ; Giovanni Pracucci ; Emilia Salvadori ; Raffaella Valenti ; Ubaldo Bonuccelli ; Paolo Cecchi ; Alberto Chiti ; Mirco Cosottini ; Giovanni Orlandi ; Cristina Pagni ; Gabriele Siciliano ; Gloria Tognoni ; Antonio Federico ; Nicola De Stefano ; Ilaria Di Donato ; Maria Teresa Dotti ; Patrizia Formichi ; Claudia Gambetti ; Antonio Giorgio ; Francesca Rossi ; Laura Stromillo ; Enza Zicari ; Paolo Zolo ; Alessandro Tiezzi ; Elisabetta Bertini ; Stefania Brotini ; Leonello Guidi ; Maria Lombardi ; Stefania Mugnai ; Antonella Notarelli ; Laura Bracco ; Massimo Cadelo ; Renzo Cisbani ; Luciano Gabbani ; Guido Gori ; Lorella Lambertucci ; Luca Massacesi ; Enrico Mossello ; Marco Paganini ; Maristella Piccininni ; Francesco Pinto ; Claudia Pozzi ; Sandro Sorbi ; Gaetano Zaccara ; Tiziano Borgogni ; Mario Mancuso ; Roberto Marconi ; Monica Mazzoni ; Marco Vista ; Giuseppe Meucci ; Giovanna Bellini ; Luciano Gabrielli ; Cristina Frittelli ; Renato Galli ; Gianna Gambaccini ; Stefano Bartolini ; Carlo Biagini ; Veronica Caleri ; Paola Vanni ; Donatella Calvani ; Carla Giorgi ; Stefano Magnolfi ; Pasquale Palumbo ; Carlo Valente ; Alessandro Rossi ; Rossana Tassi ; Stefania Boschi ; Filippo Baldacci
• 关键词：Cerebrovascular disease ; Vascular dementia ; Mild cognitive impairment ; Neuropsychology ; Cognitive aging
• 刊名：Alzheimer's & Dementia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：12
• 期：4
• 页码：407-418
• 全文大小：1073 K

文摘

Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile.

Methods

In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied.

Results

Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain.

Discussion

Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.