Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators
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- 作者：Si Nie1 ; 3 ; Huimin Ke1 ; 3 ; Feng Gao2 ; Jinqi Ren1 ; Mingzhu Wang1 ; Lin Huo1 ; Weimin Gong2 ; Wei Feng1 ; wfeng@ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：coiled-coil ; LINC complex ; nuclear envelope ; SUN protein
- 刊名：Structure
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：24
- 期：1
- 页码：80-91
- 全文大小：3585 K
文摘
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The two coiled-coil domains of SUN2 exhibit distinct oligomeric states
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CC2 forms a three-helix bundle to lock the SUN domain in an inactive conformation
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CC1 is a trimeric coiled coil for the trimerization and activation of the SUN domain
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The two coiled-coil domains of SUN2 act as the intrinsic dynamic regulators