Predictors of Delayed Intervention for Patients on Active Surveillance for Small Renal Masses: Does Renal Mass Biopsy Influence Our Decision?

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• 作者：Sapan N. Ambani^a ; ^{sapan@med.umich.edu" class="auth_mail" title="E-mail the corresponding author} ; Todd M. Morgan^a ; Jeffrey S. Montgomery^a ; Adam J. Gadzinski^b ; Bruce L. Jacobs^c ; Scott Hawken^d ; Naveen Krishnan^d ; Elaine M. Caoili^e ; James H. Ellis^e ; Lakshmi P. Kunju^f ; Khaled S. Hafez^a ; David C. Miller^a ; Ganesh S. Palapattu^a ; Alon Z. Weizer^a ; J. Stuart Wolf Jr.^a
• 刊名：Urology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：88-96
• 全文大小：216 K

文摘

To review our clinical T1a renal mass active surveillance (AS) cohort to determine whether renal mass biopsy was associated with maintenance of AS.

bsSec_2">Materials and Methods

From our prospectively maintained database we identified patients starting AS from June 2009 to December 2011 who had at least 5 months of radiologic follow-up, unless limited by unexpected death or delayed intervention. The primary outcome was delayed intervention. Clinical, radiologic, and pathologic variables were compared. We constructed Kaplan-Meier survival curves for maintenance of AS. Cox multivariable regression analysis was performed to assess predictors of delayed intervention.

bsSec_3">Results

We identified 118 patients who met criteria for inclusion with a median radiologic follow-up of 29.5 months. The delayed intervention group had greater initial mass size and faster growth rate compared to those who continued AS. Rate of renal mass biopsy was similar between the 2 groups. In the multivariable analysis, size >2 cm (hazard ratio [HR] 3.65, 95% confidence interval [CI] 1.28-10.38, P = .015), growth rate (continuous by mm/year: HR 1.26, 95% CI 1.12-1.41, P < .001), but not renal biopsy (HR 1.52, 95% CI 0.70-3.30, P = .29), were associated with increased risk of delayed intervention. Time-to-event curves also showed that size was closely associated with delayed intervention whereas renal mass biopsy was not.

bsSec_4">Conclusion

At our institution, growth rate and initial tumor size appear to be more influential than renal mass biopsy results in determining delayed intervention after a period of AS. Further analysis is required to determine the role of renal biopsy in the management of patients being considered for AS.