Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice
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- 作者：Thiago C. Santos ; Maxsuel S. Marques ; Igor A.C. Menezes ; Kellyane S. Dias ; Aline B.L. Silva ; Iderjane C.M. Mello ; Ana C.S. Carvalho ; Só ; crates C.H. Cavalcanti ; Â ; ngelo R. Antoniolli ; Rosilene
- 关键词：Hyptis suaveolens ; Antinociceptive effect ; Acute toxicity
- 刊名：Fitoterapia
- 出版年：2007
- 出版时间：July 2007
- 年：2007
- 卷：78
- 期：5
- 页码：333-336
- 全文大小：93 K
文摘
The aqueous extract of Hyptis suaveolens leaves was studied for their antinociceptive property in chemical and thermal models of nociception in mice. Oral administration of the aqueous extract (100, 200, and 400 mg/kg) dose-dependently reduced the number of writhings induced by acetic acid, decreased the licking activity of the early phase in formalin test and increased the reaction time in hot-plate test. The antinociceptive effect was significantly antagonized by naloxone (3 mg/kg; i.p.). Preliminary acute toxicity study showed that no animal death with doses up to 5 g/kg (p.o.).