Hyptis suaveolens (L.) Poit (Lamiaceae), a medicinal plant protects the stomach against several gastric ulcer models

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• 作者：N.Z.T. Jesus ; H.S. Falc茫o ; G.R.M. Lima ; M.R.D. Caldas Filho ; I.R.P. Sales ; I.F. Gomes ; S.G Santos ; J.F. Tavares ; J.M. Barbosa-Filho ; L.M. Batista
• 关键词：Hs-EtOHE ; ethanolic extract Hyptis suaveolens ; Hs-HexF ; hexanic fraction Hyptis suaveolens ; Hs-DCMF ; dicloromethanic fraction Hyptis suaveolens ; Hs-EAF ; ethil acetate fraction ; NO ; nitric oxide ; L-NAME ; l-nitro-l-arginine methyl ester ; NEM ; N-ethylmaleimide ; NSAIDs ; non-steroidal anti-inflammatory drugs
• 刊名：Journal of Ethnopharmacology
• 出版年：12 December, 2013
• 年：2013
• 卷：150
• 期：3
• 页码：982-988
• 全文大小：465 K

文摘

Ethnopharmacological relevance

Hyptis suaveolens is used by the traditional population in several parts of the world to treat inflammation, gastric ulcer and infection and is used as a crude drug to relieve symptoms related with gastric ulcer or gastritis in northeaster and central region of Brazil.

Materials and methods

the standardized ethanolic extract (Hs-EtOHE) and hexanic fraction (Hs-HexF) of Hyptis suaveolens (62,5, 125, 250 and 500 mg/kg) was evaluated in several models of acute gastric ulcers. The participation of NO was evaluated by pretreatment with L-NAME and non-protein sulfyhydryls by NEM in the gastroprotective effect.

Results

Hs-EtOHE and Hs-HexF markedly reduced the gastric lesions induced by all ulcerogenic agents (HCl/ethanol, ethanol, NSAIDs and hypothermic restraint-stress). Gastric ulcerations were exacerbated by administration of NEM suggesting that the gastroprotective mechanism of action of Hs-EtOHE and Hs-HexF involves sulfhydryl groups.

Conclusion

Ours results show that an extract of Hyptis suaveolens, administered orally to rodents, present gastro protective activity in different models of acute of gastric ulcer and give some support to the reported claims on the use of this plant as a gastro protective agent.