Taming C-terminal peptides of Staphylococcus aureus leukotoxin M for B-cell response: Implication in improved subclinical bovine mastitis diagnosis and protective efficacy in vitro
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- 作者：Radhakrishnan Jayasree Padmaja ; Prakash Motiram Halami ; prakashalami@cftri.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carboxy terminal ; Bovine mastitis ; In silico ; Rim domain ; Epitope
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：99-105
- 全文大小：1611 K
文摘
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Rim and stem domain of LukM subunit contribute to the virulent trait of leukotoxin.
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Two linear peptides of LukM C-termini comprising the domain were mapped in silico.
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Immune response to recombinant peptides probed native leukotoxin in mastitis sample.
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Peptide antibodies inhibited LukM interaction with LukF and target cell membrane.