MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury

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• 作者：Ryo Mitsugi ; Tomoo Itoh ; Ryoichi Fujiwara ; ^{fujiwarar@pharm.kitasato-u.ac.jp}
• 关键词：ABCF1 ; ATP binding cassette subfamily F member 1 ; ALT ; alanine aminotransferase ; APAF1 ; apoptotic protease activating factor 1 ; CCl4 ; carbon tetrachloride ; CHOP ; CCAAT enhancer-binding protein homologous protein ; CYP3A4 ; cytochrome P450 family 3 subfamily A member 4 ; DAX1 ; Dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome gene 1 ; GAPDH ; Glyceraldehyde-3-phosphate dehydrogenase ; HIST1H1C ; Histone cluster 1 H1c ; HIST1H2BM ; Histone cluster 1 H2bm ; HO-1
• 刊名：Toxicology Letters
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：263
• 期：Complete
• 页码：34-43
• 全文大小：1634 K
• 卷排序：263

文摘

miR-877-5p was increased in the mouse liver after the trovafloxacin administration. PEPCK expression levels were correlated with miR-877-5p expression levels. Apoptosis-associated genes were increased in miR-877-5p-overexpressed cells.