Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs

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• 作者：Dirk Schadendorf^a ; ^b ; ^{Dirk.schadendorf@uk-essen.de} ; Cé ; leste Lebbé ; ^c ; ^{celeste.lebbe@sls.aphp.fr} ; Axel zur Hausen^d ; ^{axel.zurhausen@mumc.nl} ; Marie-Franç ; oise Avril^e ; ^{marie-francoise.avril@aphp.fr} ; Subramanian Hariharan^f ; ^{s.hariharan@pfizer.com} ; Murtuza Bharmal^g ; ^{murtuza.bharmal@merckgroup.com} ; Jü ; rgen C. Becker^h ; ^{j.becker@dkfz-heidelberg.de}
• 关键词：Merkel cell carcinoma ; Skin cancer ; Merkel cell polyomavirus ; Epidemiology ; Prognosis ; Therapy
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：53-69
• 全文大小：708 K
• 卷排序：71

文摘

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a poor prognosis. MCC is associated with Merkel cell polyomavirus in more than 80% of cases. Ultraviolet radiation exposure, immunosuppression and advanced age are additional risk factors. MCC is a chemosensitive disease, but responses are generally short-lived. Although there are no approved therapies for metastatic MCC, recent immunotherapy data are encouraging.