Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma
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- 作者：Nalini Venkatesana ; b ; Jagat R. Kanwarc ; Perinkulam Ravi Deepad ; Saranya Navaneethakrishnana ; Chitra Josepha ; Subramanian Krishnakumara ; drkrishnakumar_2000@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heat shock proteins ; Survivin ; Peptido-mimetic (shepherdin) ; Retinoblastoma
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 May 2016
- 年：2016
- 卷：252
- 期：Complete
- 页码：141-149
- 全文大小：2253 K
文摘
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HSP70/90 and Survivin expressions in primary Retinoblastoma tissues are reported.
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Treatment of shepherdin, targeting HSP90/Survivin has anti-cancer effect in RB.
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Shepherdin treatment causes molecular shuffling (Bax, Bim, Bcl2, caspase-9, MMPs).
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Negligible toxicity in normal cells treated with shepherdin.
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Targeting HSP90/Survivin may be a promising adjuvant therapy for RB implicated.