Leishmania infantum antigens modulate memory cell subsets of liver resident T lymphocyte

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• 作者：A. Rodrigues^a ; M. Claro^a ; G. Alexandre-Pires^b ; D. Santos-Mateus^a ; C. Martins^c ; A. Valé ; rio-Bolas^a ; M. Rafael-Fernandes^a ; M.A. Pereira^a ; I. Pereira da Fonseca^b ; A.M. Tomá ; s^d ; G. Santos-Gomes^a ; ^{santosgomes@ihmt.unl.pt}
• 关键词：Liver resident lymphocytes ; Central memory cells ; Effector memory cells ; Leishmania infantum ; Meglumine antimoniate ; Leishmania recombinant proteins
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：222
• 期：2
• 页码：409-422
• 全文大小：3074 K
• 卷排序：222

文摘

L. infantum exerts a silencing effect on liver resident memory T cells. Meglumine antimoniate treatment promotes the expansion of liver memory T cells. Parasites less susceptible to drug suppress hepatic cytotoxic immunoresponse. Recombinant LirCyP1 and LirSOD promote the expansion of liver memory T cell subset.