Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s)
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- 作者：Siamaque Kazema ; 1 ; Chris Laubera ; 1 ; Els van der Meijdena ; Sander Kooijmana ; Alexander A. Kravchenkob ; 2 ; the TrichSpin Network ; 3
- 关键词：Codon-constrained Val-Ala (COCO-VA) toggling ; Covariation ; Intrinsically disordered protein ; Middle T antigen ; Small T antigen ; Alternative T antigen ; Phylogeny ; Polyomavirus ; Polyomavirus adaptation to human population ; Positive selection ; Short linear motif ; SLiM ; Trichodysplasia spinulosa-associated polyomavirus ; TSPyV
- 刊名：Virology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：487
- 期：Complete
- 页码：129-140
- 全文大小：1081 K
文摘
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This study represents TSPyVs of about 40% reported TS cases from three continents.
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TSPyVs genome sequences, phylogenetic distribution and evolution have been assessed.
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Thirty substitutions and two deletions accumulated along three phylogenetic lineages of 13 TSPyVs.
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Three out of four non-synonymous substitutions (NSS) were found in MT/ALTO protein.
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A NSS that may have been fixed most early in MT/ALTO shows codon-constrained Val-Ala (COCO-VA) toggling.
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Three sets of covarying genome sites have been identified.