Structural and functional diversity of nonapeptide hormones from an evolutionary perspective: A review

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• 作者：P. Banerjee^b ; K.P. Joy^a ; ^{kpjoybhu@gmail.com} ; R. Chaube^b
• 关键词：Nonapeptides ; Oxytocin/vasopressin superfamily ; Evolutionarily conserved ; Structural diversity ; Functional diversity
• 刊名：General and Comparative Endocrinology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：4-23
• 全文大小：3258 K
• 卷排序：241

文摘

Oxytocin/vasopressin-related peptides are phylogenetically old and conserved in animals. They are formed as a part of large precursor proteins and show structural diversities. They might have probably originated as neuromodulators. Later on, they acquired predominantly reproductive and osmoregulatory roles. The nonapeptide system remained a major substrate for adaptive forces during evolution.