Intraspinal transplantation of subventricular zone-derived neural progenitor cells improves phrenic motor output after high cervical spinal cord injury
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- 作者：M.S. Sandhua ; H.H. Rossa ; K.Z. Leea ; B.K. Ormerodc ; P.J. Reierb ; D.D. Fullera ; ddf@phhp.ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phrenic ; Neural precursor cells ; Plasticity ; Astrocyte
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P2
- 页码：205-215
- 全文大小：1482 K
文摘
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Neural progenitor cells (NPCs) were harvested from the forebrain sub-ventricular zone (SVZ) in neonatal rats
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NPCs were intraspinally delivered immediately caudal to acute C2 hemilesion in adult rats
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NPC transplant rats had greater inspiratory tidal volume and phrenic nerve output after 8 wks vs. sham transplants
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Histology indicated survival of ~50% of transplanted NPCs with ~90% of cells distributed in ipsilateral white matter
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Intraspinal transplantation of SVZ-derived NPCs can improve respiratory recovery following high cervical spinal cord injury.