MnTE-2-PyP reduces prostate cancer growth and metastasis by suppressing p300 activity and p300/HIF-1/CREB binding to the promoter region of the PAI-1 gene
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- 作者：Qiang Tonga ; b ; Michael R. Weaverc ; Elizabeth A. Kosmaceka ; Brian P. O'Connord ; Laura Harmacekd ; Sujatha Venkataramane ; Rebecca E. Oberley-Deegana ; becky.deegan@unmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MnTE-2-PyP ; p300 ; PAI-1 ; HIF-1β ; CREB
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：185-194
- 全文大小：1517 K
文摘
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MnTE-2-PyP combined with radiation further inhibits growth and metastasis of human prostate cancer cells.
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MnTE-2-PyP inhibits p300 HAT activity and alters p300 transcriptional complex binding to DNA.
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Specifically, MnTE-2-PyP reduces histone acetylation of the promoter of PAI-1, which is regulated by HIF-1, CREB and p300.
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This is the first study to show that MnTE-2-PyP can epigenetically regulate gene expression.