Modification of solid-state property of sulfasalazine by using the supercritical antisolvent process

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• 作者：Wei-Yi Wu ; Chie-Shaan Su ; ^{cssu@ntut.edu.tw}
• 关键词：Sulfasalazine ; Supercritical antisolvent ; Crystal habit ; Polymorph ; Particle size
• 刊名：Journal of Crystal Growth
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：460
• 期：Complete
• 页码：59-66
• 全文大小：1976 K
• 卷排序：460

文摘

Spherical micro-particles of sulfasalazine are produced by the SAS process. The effect of operating temperature in SAS is studied and discussed by MCP. Polymorph conversion during SAS is confirmed by the PXRD analysis.