Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1β and IL-6 level in rats

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• 作者：Sylwia Wrotek^a ; ^{wrotek@umk.pl} ; Krzysztof Domagalski^b ; ^{krydom@umk.pl} ; Tomasz Jędrzejewski^a ; ^{tomaszj@umk.pl} ; Eliza Dec^a ; ^{ejc.dec@gamil.com} ; Wiesław Kozak^a ; ^{wkozak@umk.pl}
• 关键词：BSO ; Fever ; Inflammation ; IL-1β ; IL-6
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：31-37
• 全文大小：729 K
• 卷排序：90

文摘

Buthionine sulfoximine (BSO) decreases spleen glutathione level. BSO inhibits endotoxic fever. BSO attenuates expression of LPS-stimulated IL-1β and IL-6 genes. BSO decreases plasma level of IL-1β and IL-6.