A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance

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• 作者：Ji-Hak Jeong¹ ; Sun-Jin Park¹ ; Shohreh Iravani Dickinson² ; Jun-Li Luo¹ ; ³ ; ^{jlluo@scripps.edu}
• 关键词：androgen deprivation therapy ; advanced prostate cancer ; castration-resistance ; constitutively activated inflammatory signaling ; NF-κB ; miR-196b-3p ; Meis2 ; PPP3CC ; castration-resistant prostate cancer ; stem cell transcription factors ; tumorigenicity
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：154-167
• 全文大小：3912 K
• 卷排序：65

文摘

A constitutive signaling circuit drives the high tumorigenicity of CRPC cells The constitutive signaling circuit is composed of miR-196b, Meis2, PPP3CC, and p65 Targeting individual components of the signaling circuit inhibits CRPC development Constitutive p65 activation in circuit is independent of traditional NF-κB pathways