Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin

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• 作者：Zhi Liu^a ; ^b ; ^c ; Wei Li^d ; Xiang Li^e ; Ming Zhang^f ; Li Chen^f ; Yi-nan Zheng^d ; Guang-zhi Sun^a ; ^c ; ^{gzsun1967@yahoo.com} ; Chang-chun Ruan^a ; ^c ; ^{changchunruan@yahoo.com}
• 关键词：Antidiabetic ; Malonyl ginsenosides ; Panax ginseng ; Type 2 diabetes
• 刊名：Journal of Ethnopharmacology
• 出版年：2013
• 出版时间：9 January, 2013
• 年：2013
• 卷：145
• 期：1
• 页码：233-240
• 全文大小：546 K

文摘

Ethnopharmacology relevance

Ginseng (Panax ginseng C. A. Meyer) has been recorded to treat ¡®Xiao-ke¡¯ (emaciation and thirst) symptom in many ancient Chinese medical literatures (such as ¡®Shen Nong Ben Cao Jing¡¯) for thousands of years. ¡®Xiao-ke¡¯ symptom, in general, indicates diabetes mellitus.

Aim of the study

Malonyl ginsenosides (MGR) are natural ginsenosides which exist in both fresh and air-dried ginseng. The objective of this study is to determine the antidiabetic function of MGR on type 2 diabetes.

Materials and methods

High fat diet-fed and streptozotocin-induced diabetic rats were treated with 50 and 100 mg/kg/d of MGR or vehicle for 3 weeks. The effects of MGR on fasting blood glucose (FBG), intraperitoneal glucose tolerance test (IPGTT), serum insulin (SI), insulin tolerance test (ITT), body weight, total cholesterol (TC), and triglyceride (TG) levels in type 2 diabetic rats were measured.

Results

After 3 weeks of treatment, MGR administration showed significantly lower FBG levels compared to the diabetic control group. In glucose tolerance test, IPGTT data showed that both MGR 50 and 100 mg/kg groups significantly increased the glucose disposal after glucose load. The ITT also showed improvement of insulin sensitivity during 120 min of insulin treatment. In addition, MGR reduced TG and TC contents while showed no effect on body weight in diabetic rats.

Conclusion

The findings from this study suggest that MGR can alleviate hyperglycemia, hyperlipemia and insulin resistance of type 2 diabetes.