Nickel(II)-induced nasal epithelial toxicity and oxidative mitochondrial damage
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- 作者：Yoon-Jin Leea ; b ; Soo-Sung Lima ; Byoung Joon Baekc ; Je-Min Anb ; Hae-Seon Namb ; Kee-Min Woob ; Moon-Kyun Chob ; Sung-Ho Kimd ; Sang-Han Leea ; b ; m1037624@sch.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nickel(II) acetate ; Nasal epithelium ; G2/M arrest ; Apoptosis ; Oxidative damage ; N-acetylcysteine
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：76-84
- 全文大小：2315 K
文摘
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Nickel(II) has growth-inhibiting and apoptosis-activating effects on RPMI-2650 cells.
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p53 is involved in arresting damaged cells at G2/M checkpoint and inducing apoptosis.
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ROS-mediated mitochondrial damage is a possible mechanism of nickel(II) toxicity.
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NAC can help protect against the harmful effects of nickel(II) on the nasal mucosa.
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