cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
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- 作者：Jin Sun Choia ; Kidae Kima ; d ; Do Hee Leeg ; Sayeon Choh ; Jae Du Haf ; Byoung Chul Parka ; d ; Sunhong Kima ; e ; sunhong@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author ; Sung Goo Parka ; c ; sgpark@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author ; Jeong-Hoon Kimb ; c ; jhoonkim@kribb.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：FALS ; SOD1 ; Ubiquitination ; cIAPs
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 November 2016
- 年：2016
- 卷：480
- 期：3
- 页码：422-428
- 全文大小：883 K
文摘
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cIAPs selectively interact with FALS-linked mutant SOD1.
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cIAPs-mutant SOD1 interaction promotes ubiquitination and degradation of mutant SOD1.
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Knock-down or pharmacologic depletion of cIAPs leads to H2O2 induced cytotoxicity in mutant SOD1 expressing cells.
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Our results reveal a novel role of cIAPs in FALS-associated mutant SOD1 regulation.