Large amino acid transporter 1 mediated glutamate modified docetaxel-loaded liposomes for glioma targeting
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- 作者：Lin Lia ; Xingsheng Dia ; Shenwu Zhanga ; Qiming Kanc ; Hao Liua ; Tianshu Lua ; Yongjun Wanga ; Qiang Fua ; Jin Suna ; b ; sunjin66@21cn.com" class="auth_mail" title="E-mail the corresponding author ; Zhonggui Hea ; hezhonggui@vip.163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：LAT1 ; Liposomes ; Docetaxel ; Glioma ; Blood&ndash ; brain-barrier
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：260-267
- 全文大小：2349 K
文摘
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Transporter-mediated nanoparticular drug delivery system.
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Large amino acid transporter 1 mediated blood–brain barrier penetration and intracranial glioma targeting.
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Docetaxel-loaded glutamate-TPGS functionalized liposomes enhanced the cell cytotoxicity.
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Glutamate-TPGS functionalized liposomes improved BBB transcytosis ability and glioma cell uptake.