Study on antitumor, antioxidant and immunoregulatory activities of the purified polyphenols from pinecone of Pinus koraiensis on tumor-bearing S180 mice in vivo

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• 作者：Juanjuan Yi^a ; Hang Qu^a ; Yunzhou Wu^b ; Zhenyu Wang^a ; ^{wangzhenyu13001@163.com} ; Lu Wang^a ; ^{hitwanglu@hit.edu.cn}
• 关键词：P. koraiensis ; Pinus koraiensis ; PPP ; polyphenols of P. koraiensis pinecone ; S180 ; sarcoma 180 ; TUNEL ; TdT-mediated dUTP nick end labeling ; O2&minus ; superoxide anions ; H2O2 ; sydrogen peroxide ; SOD ; superoxide dismutase ; GSH-Px ; glutathione peroxidasex ; GSH ; glutathione ; MDA ; malondialdehyde ; CTX ; cyclophosphamide ; PI ; phagocytic index
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：735-744
• 全文大小：3679 K
• 卷排序：94

文摘

An efficient purification method of polyphenols of Pinus koraiensis pinecone is developed. In vivo antitumor activities of the PPP-40 against xenograft Sarcoma 180 tumor cells were evaluated firstly. The mechanism of the antitumor activities of the PPP-40 were investigated by TUNEL technique and immunohistochemical method for apoptosis-related proteins Bcl-2, Bax and Caspase-3. Pinecone polyphenols are bioactive dietary constituents that enhance health and help prevent and treat cancer through improving antioxidant and immunomodulatory activities. Pinus koraiensis pinecone was proved to be a potential antitumor resource of polyphenols.