Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

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• 作者：Atheer Awad Mehde¹ ; ² ; Faridah Yusof¹ ; Wesen Adel Mehdi³ ; ^{waadmwa@yahoo.com} ; Raha Ahmed Raus¹ ; Layla Othman Farhan³ ; Jwan Abdulmohsin Zainulabdeen⁴ ; Zaima Azira Zainal Abidin⁵ ; Hamid Ghazali⁶ ; Azlina Abd Rahman⁷
• 关键词：Nephrolithiasis ; Peroxynitrite ; Nitric oxide ; E3 SUMO-protein ligase NSE2 ; Total oxidant status
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：7
• 期：3
• 页码：249-252
• 全文大小：300 K
• 卷排序：7

文摘

To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients.MethodsA total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ELISA.ResultsA significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly decreased.ConclusionsThe study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis.