Gemini surfactants from natural amino acids

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• 作者：Lourdes Pé ; rez ; Aurora Pinazo ; Ramon Pons ; MRosa Infante ; ^{rosa.infante@iqac.csic.es" class="auth_mail}
• 关键词：Gemini surfactants ; Natural amino acid-based surfactants ; Toxicity ; Aggregation ; Delivery systems
• 刊名：Advances in Colloid and Interface Science
• 出版年：March, 2014
• 年：2014
• 卷：205
• 期：Complete
• 页码：134-155
• 全文大小：1744 K

文摘

In this review, we report the most important contributions in the structure, synthesis, physicochemical (surface adsorption, aggregation and phase behaviour) and biological properties (toxicity, antimicrobial activity and biodegradation) of Gemini natural amino acid-based surfactants, and some potential applications, with an emphasis on the use of these surfactants as non-viral delivery system agents. Gemini surfactants derived from basic (Arg, Lys), neutral (Ser, Ala, Sar), acid (Asp) and sulphur containing amino acids (Cys) as polar head groups, and Geminis with amino acids/peptides in the spacer chain are reviewed.