Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
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- 作者：Victor S. Cortez1 ; Luisa Cervantes-Barragan1 ; Michelle L. Robinette1 ; Jennifer K. Bando1 ; Yaming Wang1 ; Theresa L. Geiger2 ; Susan Gilfillan1 ; Anja Fuchs3 ; Eric Vivier4 ; Joe C. Sun2 ; Marina Cella1 ; Marco Colonna1 ; mcolonna@pathology.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：innate lymphoid cells ; salivary gland ; TGF-β ; development ; signaling ; transcription factors
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1127-1139
- 全文大小：3656 K
文摘
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TGF-β is required for SG ILC differentiation
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TGF-β promotes SG ILC differentiation by suppressing Eomes
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TGF-β acts through a non-canonical Smad4-independent pathway
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SG ILCs have features of both ILC1 and NK cells