Functional Human Oocytes Generated by Transfer of Polar Body Genomes

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• 作者：Hong Ma¹ ; ⁸ ; Ryan C. O&rsquo ; Neil² ; ³ ; ⁸ ; Nuria Marti Gutierrez¹ ; Manoj Hariharan² ; Zhuzhu Z. Zhang² ; Yupeng He² ; ³ ; Cengiz Cinnioglu⁴ ; Refik Kayali⁴ ; Eunju Kang¹ ; Yeonmi Lee¹ ; Tomonari Hayama¹ ; Amy Koski¹ ; Joseph Nery² ; Rosa Castanon² ; Rebecca Tippner-Hedges¹ ; Riffat Ahmed¹ ; Crystal Van Dyken¹ ; Ying Li¹ ; Susan Olson⁵ ; David Battaglia⁶ ; David M. Lee⁶ ; Diana H. Wu⁶ ; Paula Amato⁶ ; Don P. Wolf¹ ; Joseph R. Ecker² ; ⁷ ; ^{ecker@salk.edu} ; Shoukhrat Mitalipov¹ ; ⁶ ; ⁹ ; ^{mitalipo@ohsu.edu}
• 关键词：polar body nuclear transfer ; meiosis ; haploid ; reconstructed human oocytes ; infertility treatment ; mitochondrial replacement therapy
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：112-119
• 全文大小：2405 K
• 卷排序：20

文摘

Metaphase II oocytes can be reconstructed by polar body nuclear transfer (PBNT) Reconstructed PBNT oocytes complete meiosis after fertilization with sperm PBNT-derived blastocysts can give rise to phenotypically normal hESC lines