Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21WAF1 in mesangial cells
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- 作者：Sheng-Hsuan Lina ; Wan-Ting Hoa ; Yeng-Tseng Wangb ; Chao-Tang Chuanga ; Lea-Yea Chuangb ; chuangly@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jinn-Yuh Guhc ; d ; guhjy@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; guhjy1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Suv39h1 ; Suppressor of variegation 3⿿9 homolog 1 ; DN ; diabetic nephropathy ; H3K9me3 ; trimethylated lysine 9 of histone H3 ; HG ; high glucose ; HMT ; histone lysine methyltransferase ; PI3K ; phosphoinositide 3-kinase ; TGFβ ; transforming growth factor-β ; ERK ; extracellular signal-regulated kinase JNK ; c-Jun N-terminal kinase ; GSK3 ; glycogen synthase kinase-3 ; JAK-STAT ; Janus kinase-signal transducers and activators of transduction ; H3K9Ac ; acetylation at lysine 9 of histone H3 ; VSMC ; vascular smooth m
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：96-105
- 全文大小：2060 K
文摘
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High glucose decreased Suv39h1 levels via PI3K in mesangial cells.
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High glucose and chaetocin decreased histone H3K9me3 levels at the promoters of fibronectin and p21WAF1 genes.
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Suv39h1 overexpression attenuated high glucose-induced cell hypertrophy and expressions of fibronectin and p21WAF1 genes while attenuating HG-suppressed histone H3K9me3 levels at the promoters of fibronectin and p21WAF1 genes.