q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with fingolimod: A preliminary study

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• 作者：Mariko Tanikawa^a ; Jin Nakahara^a ; ^{nakahara@a6.keio.jp} ; Junichi Hata^b ; ^c ; Shigeaki Suzuki^a ; Kanehiro Fujiyoshi^d ; ^e ; Hirokazu Fujiwara^f ; Suketaka Momoshima^f ; Masahiro Jinzaki^f ; Masaya Nakamura^d ; Hideyuki Okano^b ; ^c ; Shinichi Takahashi^a ; Norihiro Suzuki^a ; ^{nrsuzuki@a2.keio.jp}
• 关键词：Multiple sclerosis ; Fingolimod ; Remyelination ; MRI ; q-Space Myelin Map
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：373
• 期：Complete
• 页码：352-357
• 全文大小：954 K
• 卷排序：373

文摘

q-Space Myelin Mapping is a novel MRI modality for specifically visualizing myelin. Fingolimod (FTY) has been shown to induce remyelination in certain animal studies. Remyelination in FTY-treated multiple sclerosis brains was seen with Myelin Mapping. The possible role of FTY in the induction of remyelination awaits further studies.