Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1

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• 作者：Luca Popescu^a ; Natasha N. Gaudreault^a ; ^{nng5757@vet.k-state.edu} ; Kristen M. Whitworth^b ; Maria V. Murgia^a ; Jerome C. Nietfeld^a ; Alan Mileham^c ; Melissa Samuel^b ; Kevin D. Wells^b ; Randall S. Prather^b ; Raymond R.R. Rowland^a
• 关键词：African swine fever ; Virus ; Receptor ; CD163
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：102-106
• 全文大小：434 K
• 卷排序：501

文摘

CD163 has been proposed as the receptor for African swine fever virus. Gene-edited pigs lacking CD163 were infected with African swine fever virus. No differences in infection or disease were observed compared to wild type pigs. CD163 does not play a significant role in African swine fever virus infection.