Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

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• 作者：Xinru Liu ; Fuhang Song ; Li Ma ; Caixia Chen ; Xue Xiao ; Biao Ren ; Xueting Liu ; Huanqin Dai ; Andrew M. Piggott ; Yossef Av-Gay ; Lixin Zhang ; Robert J. Capon
• 关键词：AEIWRRLKRYHZRZ-UHFFFAOYSA-N ; LHFVFGQTOMNUAT-UHFFFAOYSA-N ; QOPXRCMKGKMOSI-UHFFFAOYSA-N
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：6 November, 2013
• 年：2013
• 卷：54
• 期：45
• 页码：6081-6083
• 全文大小：303 K

文摘

Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (class=""boldFont"">1-class=""boldFont"">3), and two known bis-pyrogallol ethers, violaceols I (class=""boldFont"">4) and II (class=""boldFont"">5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (class=""boldFont"">1) and C (class=""boldFont"">3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).