Renal sympathetic denervation suppresses atrial fibrillation induced by acute atrial ischemia/infarction through inhibition of cardiac sympathetic activity

详细信息    查看全文

• 作者：Qina Zhou^a ; Xianhui Zhou^b ; ZuKe-la TuEr-Hong^b ; Hongli Wang^c ; Tingting Yin^b ; Yaodong Li^b ; Ling Zhang^b ; Yanmei Lu^b ; Qiang Xing^b ; Jianghua Zhang^b ; Yining Yang^c ; ^{yagnyin5126@163.com" class="auth_mail" title="E-mail the corresponding author} ; Baopeng Tang^b ; ^{tangbaopeng1111@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Renal sympathetic denervation ; Atrial fibrillation ; Sympathetic activity ; Ischemia ; Infarction
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：203
• 期：Complete
• 页码：187-195
• 全文大小：1565 K

文摘

This study aims to explore the effects of renal sympathetic denervation (RSD) on atrial fibrillation (AF) inducibility and sympathetic activity induced by acute atrial ischemia/infarction.

Methods

Acute ischemia/infarction was induced in 12 beagle dogs by ligating coronary arteries that supply the atria. Six dogs in the sham-RSD group did not undergo RSD, and six dogs without coronary artery ligation served as controls. AF induction rate, sympathetic discharge, catecholamine concentration and densities of tyrosine hydroxylase-positive nerves were measured.

Results

Acute atrial ischemia/infarction resulted in a significant increase of AF induction rate, which was decreased by RSD compared to controls (P < 0.05). The root-mean-square peak value, peak area and number of sympathetic discharges were significantly augmented by atrial ischemia relative to the baseline and control (P < 0.05). The number of sympathetic discharges was significantly reduced in the RSD group, compared to the control and sham-RSD groups (P < 0.05). Norepinephrine and epinephrine concentrations in the atria, ventricle and kidney were elevated by atrial ischemia/infarction, but were reduced by RSD (P < 0.05).

Conclusions

Sympathetic hyperactivity was associated with pacing-induced AF after acute atrial ischemia/infarction. RSD has the potential to reduce the incidence of new-onset AF after acute atrial ischemia/infarction. The inhibition of cardiac sympathetic activity by RSD may be one of the major underlying mechanisms for the marked reduction of AF inducibility.