KCNE1 and KCNE3: The yin and yang of voltage-gated K+ channel regulation
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- 作者：Geoffrey W. Abbott abbottg@uci.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AV block ; atrioventricular block ; BLAST ; basic local alignment search tool ; cAMP ; cyclic adenosine monophosphate ; Cav channel ; voltage-gated calcium channel ; CHO ; Chinese Hamster ovary ; di ; drug-induced ; ERRγ ; estrogen-related receptor γ ; EST ; expressed sequence tag ; fs ; frameshift ; HCN ; hyperpolarization-activated ; cyclic nucleotide-gated ; HEK ; human embryonic kidney ; IKs/IsK ; slowly activating K+ current ; JLNS ; Jervell and Lange&ndash ; Nielsen syndrome ; KChIP ; K+ channel interacting protein ; Kv
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：1-13
- 全文大小：1086 K
文摘
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KCNE1 and KCNE3 regulate K+ channel gating, voltage dependence and trafficking
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KCNE1 and 3 often have opposite effects on channel function, especially so for KCNQ1
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KCNE1-KCNQ1 channels are best known for their role in cardiomyocyte repolarization
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KCNE3-KCNQ1 channels are important in various secretory epithelia
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Human KCNE1 and KCNE3 sequence variants cause various cardiac arrhythmias