Total synthesis of ibogaine, epiibogaine and their analogues

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• 作者：Goutam Kumar Jana ; Surajit Sinha
• 关键词：Iboga alkaloids ; Reductive-Heck coupling ; Indoloazepine ring ; Isoquinuclidine
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：2 September, 2012
• 年：2012
• 卷：68
• 期：35
• 页码：7155-7165
• 全文大小：1180 K

文摘

Efficient total synthesis of ibogaine, epiibogaine and their analogues has been described. An intramolecular reductive-Heck type cyclization was used for the construction of seven-membered indoloazepine ring to access iboga-skeleton. Larock¡¯s heteroannulation reaction was employed for the creation of suitably substituted indole and Diels-Alder reaction was employed for the construction of the isoquinuclidine ring present in iboga alkaloids.