IFNy + and IFNy − Treg subsets with stable and unstable Foxp3 expression in kidney transplant recipients with good long-term graft function
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- 作者：Karina Trojana ; Karina.Trojan@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Christian Unterrainera ; Christian.Unterrainer@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Mostafa Alya ; Mostafa.Aly@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Li Zhua ; Li.Zhu@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Rolf Weimerb ; Rolf.Weimer@innere.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Nuray Bulutb ; Nuray.Bulut@innere.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Christian Morathc ; Christian.Morath@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Gerhard Opelza ; Gerhard.Opelz@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Volker Daniela ; Volker.Daniel@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：APO1/FasR ; Apoptosis antigen 1/Fas receptor (CD95) ; FasL ; Fas ligand (CD178) ; Treg ; Regulatory T-cell ; IL ; Interleukin ; TGFβ ; Transforming growth factor-beta ; IFNy ; Interferon-gamma ; IFNyR1 ; Interferon-gamma receptor 1 ; PBL ; Peripheral blood lymphocytes ; Tbet ; T-box expressed in T-cells ; CTLA4 ; Cytotoxic T-lymphocyte-associated protein 4 ; CD40L ; CD40 ligand (CD154) ; CXCR3 ; CXC-motive-chemokine-receptor 3 (CD183) ; PD1 ; Programmed cell death 1 (CD279) ; Fab ; Fragment antigen binding ; HRM ; High reso
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：1-9
- 全文大小：734 K
文摘
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Treg with stable and unstable Foxp3 expression might regulate the immune system.
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Both types of Treg can express IFNy and both IFNy- and IFNy+ Treg appear to have clinical relevance.
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They modulate effector cells via TGFß, CTLA4, perforin, FasL and consumption of IFNy and IL2.
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We believe that these Treg modulate alloreactivity of T- and B-lymphocytes as well as NK cells.
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We believe that they have a potential of allowing reduction of immunosuppressive drugs to low maintenance levels.
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