Migraine and Risk of Ocular Motor Cranial Nerve Palsies: A Nationwide Cohort Study

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• 作者：Chun-Pai Yang ; MD ; PhD¹ ; ² ; ^&lowast ; ; Yung-Tai Chen ; MD³ ; ⁴ ; ^&lowast ; ; Jong-Ling Fuh ; MD³ ; ⁵ ; Shuu-Jiun Wang ; MD³ ; ⁵ ; ⁶ ; ^{sjwang@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CI ; confidence interval ; CN ; cranial nerve ; HR ; hazard ratio ; ICD-9-CM ; International Classification of Diseases ; 9th Revision ; Clinical Modification ; NHI ; National Health Insurance ; NHIRD ; National Health Insurance Research Database ; OMCNP ; ocular motor cranial nerve palsies ; NT$ ; new Taiwan dollars ; SD ; standard deviation
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：123
• 期：1
• 页码：191-197
• 全文大小：230 K

文摘

To determine whether migraine is associated with an increased risk of developing ocular motor cranial nerve palsies (OMCNP).

Design

Nationwide retrospective cohort study.

Participants

Medical records of patients with migraine who were entered in the National Health Insurance Research Database (NHIRD) between 2005 and 2009 were retrieved from the NHIRD in Taiwan. Two cohorts were selected: patients with migraine (n = 138 907) and propensity score–matched controls (n = 138 907).

Main Outcome Measures

Cohorts were followed until the end of 2010, death, or occurrence of cranial nerve (CN)3, CN4, or CN6 palsies. A Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs), which were used to compare to the risk of developing CN3, CN4, and CN6 palsy between cohorts.

Results

After a mean follow-up period of 3.1 years (range, 1–6 years), the migraine cohort exhibited a greater risk of developing subsequent CN3, CN4, and CN6 palsies compared with the control cohort (HR, 2.67, P < 0.001; HR, 4.23, P < 0.001; HR, 3.37; P < 0.001). This finding was maintained after excluding potential confounders during sensitivity tests. Moreover, the significant association between migraine and OMCNP remained after we adjusted for potential risk factors of microvascular ischemia. However, different migraine subtypes showed no significant differences.

Conclusions

Migraine is an unrecognized risk factor for OMCNP development in adults. Further studies are needed to validate our findings and to delineate the exact pathophysiologic mechanisms linking migraine and OMCNP.