Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation
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- 作者：Jiajia Liu1 ; 2 ; Yong-Mei Guo1 ; Nobuyuki Onai3 ; 4 ; Hideaki Ohyagi1 ; Makoto Hirokawa5 ; Naoto Takahashi1 ; Hiroyuki Tagawa1 ; Kumi Ubukawa1 ; Isuzu Kobayashi1 ; Hiroyuki Tezuka6 ; Yoshihiro Minamiya2 ; Toshiaki Ohteki3 ; 4 ; Kenichi Sawada7 ; ksawada@doc.med.akita-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytosine-phosphorothionate-guanine oligodeoxynucleotide (CpG-ODN) ; TNF-α ; IFN-γ ; Bone marrow transplantation ; Hemophagocytic syndrome
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：4
- 页码：627-636
- 全文大小：2553 K
文摘
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Hemophagocytosis is a common feature of all mice early after bone marrow transplantation.
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Toll-like receptor 9 ligand exacerbates hemophagocytosis by inducing TNF-α production in all mice that had undergone bone marrow transplantation. The effect can be blocked by using a TNF inhibitor.