Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells
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- 作者：Naruyoshi Fujiwara ; Jun Shimizu ; Kenji Takai ; Nagisa Arimitsu ; Yuji Ueda ; Sueshige Wakisaka ; Tomoko Suzuki ; Noboru Suzuki ; n3suzuki@marianna-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dementia ; Human iPS ; Cholinergic neuron ; GABAergic neuron ; Transplantation ; Nerve regeneration
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：271
- 期：Complete
- 页码：423-431
- 全文大小：2432 K
文摘
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hiPS cell derived neurons expressed choline acetyltransferase and GABA transporter (82).
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The neuron transplantation improved cognitive dysfunction of dementia model mice (81).
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Human Cholinergic neurons located in the cortex with the receptor positive cells (82)
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Human GABAergic neurons remained in the hippocampus and partly located in the cortex (85).
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The human grafts may reduce both cholinergic and GABAergic dysfunction of the model (84).