- 作者：Toshihiro Kimura ; Takashi Miyatake ; Yutaka Ueda ; Yukinobu Ohta ; Takayuki Enomoto ; Tadashi Kimura ; Shoji Kamiura
- 关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; AUC ; area under the plasma drug concentration versus time curve ; CCRT ; concurrent chemoradiotherapy ; CR ; complete response ; G-CSF ; granulocyte-colony stimulating factor ; 5-HT3 ; 5-hydroxytript
- 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：164
- 期：2
- 页码：200-204
- 全文大小：222 K
Objective
An effective salvage chemotherapy for advanced and recurrent non-squamous carcinoma of the uterine cervix has not yet been established. The aim of the present study was to analyze the safety and efficacy of a combination chemotherapy for this disease using taxane, anthracycline, and platinum.Study design
This was a retrospective analysis of advanced and recurrent non-squamous cervical cancers treated at the Osaka University Hospital and the Osaka Medical Center for Cancer and Cardiovascular Diseases during a 10 year study period from 2000 to 2009. Single agent chemotherapies and combination chemotherapies for advanced and recurrent cervical cancer cases of non-squamous histology which were reported in the English literature were also reviewed.
Results
Salvage chemotherapy, using taxane, anthracycline and platinum, was performed for 5 advanced and 14 recurrent cases. Prior to the salvage chemotherapy, 15 (79 % ) of the 19 patients had already received either radiation or chemotherapy. A complete or partial tumor response was achieved in 8 (42 % ) of the 19 cases. The response rate for recurrent disease in a previously irradiated field was 40 % . The median progression-free survival (PFS) and overall survival (OS) were 8 months (1-108) and 13 months (5-108), respectively. Grade 4 and febrile grade 3 neutropenia was observed in 6 cases (32 % ), but there was no case in which salvage chemotherapy had to be cancelled due to toxicity. According to previous reports, the cumulative response rate of combination chemotherapy (35 % ) was significantly higher than that of single agent chemotherapy (17 % ) (p < 0.001). OS tended to be longer in the combination chemotherapy cases (8.7 months to 18 months) than that of single agent chemotherapy cases (7.3+ months to 9.1+ months).
Conclusion
Combination chemotherapy of taxane, anthracycline, and platinum was found to have a survival benefit for advanced and recurrent cervical cancer patients of non-squamous carcinoma histology, with a tolerable toxicity.