Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways

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• 作者：Komaki ; Yuichi ; Sugiura ; Hisatoshi ; Koarai ; Akira ; Tomaki ; Masafumi ; Ogawa ; Hiromasa ; Akita ; Takefumi ; et. al.
• 关键词：Oxidative stress ; Superoxide ; TNF-α ; IL-1β ; IFN-γ
• 刊名：Pulmonary Pharmacology & Therapeutics
• 出版年：2005
• 出版时间：August, 2005
• 年：2005
• 卷：18
• 期：4
• 页码：297-302
• 全文大小：126 K

文摘

Reactive oxygen species have been reported to be involved in the airway inflammatory process of chronic obstructive pulmonary disease (COPD). The aim of this study was to quantify the activity of xanthine oxidase (XO), which generates a potent radical superoxide anion in COPD airways.