MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease
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- 作者：Ayano Takeuchi-Yorimotoa ; b ; ayano.takeuchi@astellas.com" class="auth_mail" title="E-mail the corresponding author ; Yu Yamaurab ; Masayuki Kankib ; Tetsuya Ideb ; Ayumi Nakatac ; Takahisa Notob ; d ; Masahiro Matsumotob
- 关键词：NASH ; Fibrosis ; CDAA ; MiR-21
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：258
- 期：Complete
- 页码：159-167
- 全文大小：2424 K
文摘
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Hepatic fibrosis is associated with miR-21 and Mmp-9 and Timp-1 mRNAs.
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miRNA-21 has potential as a plasma biomarker for hepatic fibrosis.
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The pathogenesis of hepatic fibrosis is associated with 16 miRNAs and 11 mRNAs.