KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting
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- 作者：Yoshinori Takeuchi1 ; Naoya Yahagi1 ; 6 ; nyahagi-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuichi Aita1 ; Yuki Murayama1 ; Yoshikazu Sawada1 ; Xiaoying Piao1 ; Naoki Toya1 ; Yukari Oya1 ; Akito Shikama1 ; Ayako Takarada1 ; Yukari Masuda1 ; Makiko Nishi1 ; Midori Kubota1 ; Yoshihiko Izumida1 ; Takashi Yamamoto2 ; Motohiro Sekiya2 ; Takashi Matsuzaka2 ; Yoshimi Nakagawa2 ; Osamu Urayama2 ; Yasushi Kawakami2 ; Yoko Iizuka3 ; Takanari Gotoda3 ; Keiji Itaka4 ; Kazunori Kataoka4 ; Ryozo Nagai3 ; Takashi Kadowaki3 ; Nobuhiro Yamada2 ; Yuan Lu5 ; Mukesh K. Jain5 ; Hitoshi Shimano2
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：16
- 期：9
- 页码：2373-2386
- 全文大小：4113 K
文摘
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A transcription factor library screen reveals a complex between KLF15 and LXR/RXR
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KLF15 interacts with LXR/RXR and recruits the RIP140 corepressor to the Srebf1c promoter
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This enables rapid switching between lipogenesis and gluconeogenesis during fasting
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Hepatic KLF15 augmentation improves the plasma lipid profile
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