Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review

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• 作者：Ryuki Hashida¹ ; ² ; Takumi Kawaguchi³ ; ^{takumi@med.kurume-u.ac.jp} ; Masafumi Bekki¹ ; ² ; Masayuki Omoto¹ ; ² ; Hiroo Matsuse¹ ; ² ; Takeshi Nago¹ ; ² ; Yoshio Takano⁴ ; Takato Ueno⁵ ; ⁶ ; Hironori Koga³ ; ⁶ ; Jacob George⁷ ; Naoto Shiba¹ ; ² ; Takuji Torimura³ ; ⁶
• 关键词：Aerobic training ; Resistance training ; Exercise energy consumption ; Adipokine ; Myokine
• 刊名：Journal of Hepatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：1
• 页码：142-152
• 全文大小：3007 K
• 卷排序：66

文摘

Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease (NAFLD). We sought to: 1) summarize effective aerobic and resistance exercise protocols for NAFLD; and 2) compare the effects and energy consumption of aerobic and resistance exercises.MethodsA literature search was performed using PubMed, Web of Science, and Scopas to January 28, 2016. From a total of 95 articles, 23 studies including 24 aerobic and 7 resistance exercise protocols were selected for the summary of exercise protocols. Twelve articles including 13 aerobic and 4 resistance exercise protocols were selected for the comparative analysis.ResultsFor aerobic exercise, the median effective protocol was 4.8 metabolic equivalents (METs) for 40 min/session, 3 times/week for 12 weeks. For resistance exercise, the median effective protocol was 3.5 METs for 45 min/session, 3 times/week for 12 weeks. Aerobic and resistance exercise improved hepatic steatosis. No significant difference was seen in the duration, frequency, or period of exercise between the two exercise groups; however, %VO2max and energy consumption were significantly lower in the resistance than in the aerobic group (50% [45–98] vs. 28% [28–28], p = 0.0034; 11,064 [6394–21,087] vs. 6470 [4104–12,310] kcal/total period, p = 0.0475).ConclusionsResistance exercise improves NAFLD with less energy consumption. Thus, resistance exercise may be more feasible than aerobic exercise for NAFLD patients with poor cardiorespiratory fitness or for those who cannot tolerate or participate in aerobic exercise. These data may indicate a possible link between resistance exercise and lipid metabolism in the liver.Lay summaryBoth aerobic and resistance exercise reduce hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) with similar frequency, duration, and period of exercise (40–45 min/session 3 times/week for 12 weeks); however, the two forms of exercise have different characteristics. Intensity and energy consumption were significantly lower for resistance than for aerobic exercise. Resistance exercise may be more feasible than aerobic exercise for NAFLD patients with poor cardiorespiratory fitness or for those who cannot tolerate or participate in aerobic exercise.