Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity
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- 作者：Tatsuma Ban1 ; 8 ; Go R. Sato1 ; 8 ; Akira Nishiyama1 ; Ai Akiyama1 ; Marie Takasuna1 ; Marina Umehara1 ; Shinsuke Suzuki1 ; 2 ; Motohide Ichino1 ; Satoko Matsunaga3 ; Ayuko Kimura4 ; Yayoi Kimura4 ; Hideyuki Yanai5 ; Sadakazu Miyashita6 ; Junro Kuromitsu6 ; Kappei Tsukahara6 ; Kentaro Yoshimatsu6 ; Itaru Endo2 ; Tadashi Yamamoto7 ; Hisashi Hirano4 ; Akihide Ryo3 ; Tadatsugu Taniguchi5 ; Tomohiko Tamura1 ; tamurat@yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：45
- 期：2
- 页码：319-332
- 全文大小：4938 K
文摘
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Lyn binds to and inhibits the activity of IRF5 in the TLR-MyD88 pathway
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Lyn inhibits post-translational modifications of IRF5 without Lyn’s kinase activity
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Lyn deficiency causes IRF5 hyperactivation in DCs
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SLE symptoms in Lyn–/– mice are ameliorated by monoallelic deletion of Irf5