At the crossroads of cancer stem cells and targeted therapy resistance

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• 作者：Anbang Wang^a ; Le Qu^b ; ^{septsoul@hotmail.com} ; Linhui Wang^a ; ^{wanglinhuicz@163.com}
• 关键词：Targeted therapy ; Cancer stem cells ; Targeted therapy resistance ; Combinational therapy ; Anti-CSC therapy
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：87-96
• 全文大小：809 K
• 卷排序：385

文摘

CSCs are activated by TT-induced tumor environment and epigenetic modifications. CSCs mediate TTR through self-renewal, survival ability, drug efflux and dormancy. Combination treatment of TT with anti-CSC agents improve the efficacy of TT. The application of anti-CSC therapy necessitate several careful considerations.